Naproxen evolan huvudvärk
Kontraindiceret, øget bivirkningsrisiko. GFR ml/min. Prostaglandiner har betydning for opretholdelse af normal nyregennemblødning. NSAID's hæmning af prostaglandinsyntesen kan derfor forårsage nedsat nyregennemblødning og dermed forværret nyrefunktion. Naproxen , sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug NSAID used to treat pain, menstrual cramps , and inflammatory diseases such as rheumatoid arthritis , gout and fever.
Common side effects include dizziness , headache , bruising , allergic reactions , heartburn , and stomach pain. Naproxen is a nonselective COX inhibitor. Naproxen was patented in , and approved for medical use in the United States in Naproxen's medical uses are related to its mechanism of action as an anti-inflammatory compound. Naproxen sodium is used as a "bridge therapy" in medication-overuse headache to slowly take patients off other medications.
Naproxen sodium is available as both an immediate release and as an extended release tablet. The extended release formulations sometimes called "sustained release", or "enteric coated" take longer to take effect than the immediate release formulations, and therefore are less useful when immediate pain relief is desired. Extended release formulations are more useful for the treatment of chronic, or long-lasting, conditions, in which long-term pain relief is desirable.
Naproxen (oral route)
As with all non-steroidal anti-inflammatory medications NSAIDs , naproxen use should be avoided in pregnancy due to the importance of prostaglandins in vascular and renal function in the fetus. NSAIDs should especially be avoided in the third trimester. Small amounts of naproxen are excreted in breast milk. Common adverse effects include dizziness, drowsiness, headache, rash, bruising, and gastrointestinal upset.
In October , the U. Food and Drug Administration FDA required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. As with other non- COX-2 selective NSAIDs, naproxen can cause gastrointestinal problems , such as heartburn, constipation, diarrhea, ulcers and stomach bleeding. COX-2 selective and nonselective NSAIDs have been linked to increases in the number of serious and potentially fatal cardiovascular events, such as myocardial infarctions and strokes.
A study found that high-dose naproxen induced near-complete suppression of platelet thromboxane throughout the dosing interval and appeared not to increase cardiovascular disease CVD risk, whereas other non-aspirin high-dose NSAID regimens had only transient effects on platelet COX-1 and were associated with a small but definite vascular hazard. Conversely, naproxen was associated with higher rates of upper gastrointestinal bleeding complications compared with other NSAIDs.
Naproxen may interact with antidepressants , lithium , methotrexate , probenecid , warfarin and other blood thinners , heart or blood pressure medications, including diuretics , or steroid medicines such as prednisone.
NSAIDs such as naproxen may interfere with and reduce the efficacy of SSRI antidepressants, [ 31 ] as well as increase the risk of bleeding greater than the individual bleeding risk of either class of agent, when taken together. It is extensively metabolized in the liver to 6-O-desmethylnaproxen, and both the parent drug and the desmethyl metabolite undergo further metabolism to their respective acylglucuronide conjugated metabolites.
The pharmacogenetics of naproxen has been studied in an effort to better understand its adverse effects. Naproxen has a melting point of — °C , while naproxen salts tend to have higher melting points.
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Naproxen has been industrially produced by Syntex starting from 2-naphthol as follows: [ 42 ]. Syntex first marketed naproxen in , as the prescription drug Naprosyn. They first marketed naproxen sodium under the brand name Anaprox in It remains a prescription-only drug in much of the world. OTC preparations of naproxen in the U. In the United Kingdom, mg tablets of naproxen were approved for OTC sale under the brand name Feminax Ultra in , for the treatment of primary dysmenorrhoea in women aged 15 to Aleve became available over the counter in some provinces in Canada [ 46 ] on 14 July , but not British Columbia , Quebec or Newfoundland and Labrador ; [ 47 ] it subsequently became available OTC in British Columbia in January Naproxen was one of the four substances named in the prosecution of Industrial Bio-Test Laboratories IBT for fraudulent toxicology testing.
Naproxen has been found in groundwater and drinking water in concentrations high enough to have adverse effects on invertebrates including fungi, algae, bacteria and fishes. Naproxen may have antiviral activity against influenza. In laboratory research, it blocks the RNA-binding groove of the nucleoprotein of the virus, preventing formation of the ribonucleoprotein complex—thus taking the viral nucleoproteins out of circulation.
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